Role of Nod-like receptor pyrin domain 3 inflammasome and pyroptosis in bronchial asthma
10.3760/cma.j.cn101070-20200226-00256
- VernacularTitle:Nod样受体蛋白3炎性小体及细胞焦亡在支气管哮喘中的作用
- Author:
Fan LIU
1
;
Xiuzhen HAN
;
Yan SUN
Author Information
1. 山东第一医科大学附属省立医院，山东大学附属省立医院儿科，济南 250021
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(12):955-957
- CountryChina
- Language:Chinese
-
Abstract:
The role of Nod-like receptor pyrin domain 3 (NLRP3) inflammasome and pyroptosis in bronchial asthma (asthma) has attracted increasing attention in recent years.The activation of NLRP3 leads to the recruitment and activation of Cysteinyl aspartate specific proteinase-1 and the release of interleukin-1β(IL-1β) and interleukin-18(IL-18), which aggravates the airway inflammation in asthma.Meanwhile, NLRP3 further results in the clea-vage of Gasdermin D and pyroptosis.Finally, the cell damage stimulates the airway remodeling of asthma.This article focused on the mechanisms of NLRP3 inflammatory response and pyroptosis as well as its role in asthma.
