Recent progress of host susceptibility gene polymorphisms in Isoniazid induced liver injury
10.3760/cma.j.cn101070-20200220-00200
- VernacularTitle:异烟肼致肝损伤的宿主易感基因多态性研究进展
- Author:
Hui QI
1
;
Chen SHEN
;
Yingjia LI
;
Adong SHEN
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院，北京市儿科研究所，儿科学国家重点学科，国家呼吸系统疾病临床医学研究中心，儿科重大疾病研究教育部重点实验室，儿童呼吸道感染性疾病研究北京市重点实验室，北京 100045
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(10):762-766
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis (TB) is an infectious fatal disease that seriously endangers human health worldwide.Isoniazid (INH) is an important first-line drug for TB, but it can cause serious adverse drug reactions, such as liver injury and even liver failure.At present, it is believed that metabolites of INH, imbalance of oxidative stress responses and immune response disorders are major causes of INH induced liver injury.In addition, involved genes and gene polymorphisms are susceptible to liver injury caused by INH.In this paper, the association of INH induced liver injury with the polymorphisms of genes related to INH metabolizing enzymes, as well as oxidative stress and immune responses are summarized to improve the understanding of INH induced liver injury and provide novel directions for its prevention and treatment.
