Progress in application of new biological biomarkers in the diagnosis of pediatric tuberculosis
10.3760/cma.j.cn101070-20200220-00201
- VernacularTitle:新型生物标志物在儿童结核病诊断中的应用进展
- Author:
Jing XIAO
1
;
Weiwei JIAO
;
Adong SHEN
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院，北京市儿科研究所，儿科学国家重点学科，国家呼吸系统疾病临床医学研究中心，儿科重大疾病研究教育部重点实验室，儿童呼吸道感染性疾病研究北京市重点实验室，北京 100045
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(10):737-743
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis is still a serious disease threatening children′s health.The detection and early diagnosis of tuberculosis in children still face many problems, such as the low detection rate and high misdiagnosis rate from traditional methods, the difficulty of collection and low bacterial load of sputum specimens from children, and difficult diagnosis of extrapulmonary tuberculosis.Therefore, there is an urgent need to find new diagnostic markers for rapid, sensitive and efficient diagnosis of tuberculosis, and biomarkers point out the direction for us.In this review, progress in the application of new biological biomarkers of pediatric tuberculosis was summarized from the transcriptomic, proteomic, metabolomic and microRNA aspects.
