Adverse reactions of anti-tuberculosis drugs in children and treatment strategies
10.3760/cma.j.cn101070-20200217-00175
- VernacularTitle:儿童抗结核药物不良反应及处理对策
- Author:
Yang LIU
1
;
Chaomin WAN
Author Information
1. 四川大学华西第二医院儿科，出生缺陷与相关幼儿疾病教育部重点实验室，成都 610041
- From:
Chinese Journal of Applied Clinical Pediatrics
2020;35(10):770-774
- CountryChina
- Language:Chinese
-
Abstract:
Currently, pediatric tuberculosis is still a serious infectious disease endangering pediatric health, and anti-tuberculosis (TB) therapy is the major treatment for this disease.The course of anti-TB treatment in children is generally long and requires multi-drug combination, which significantly increases the risk of adverse drug reactions(ADRs). Therefore, it is important for pediatricians to have an intimate knowledge of ADRs and countermeasures.The common ADRs in children include anti-TB drug-induced liver injury, skin adverse reactions, gastrointestinal reactions, drug fever, and post-bulbous neuritis.For children with mild and tolerable ADRs, symptomatic treatment should be performed and anti-TB treatment continued.If the adverse reaction is serious or cannot be tolerated, the drug should be stopped in time.If ADRs are complex, serious or rare, multidisciplinary discussion should be conducted to make the best clinical decision.
