The mechanism of Huanglian-Ejiao Decoction in the treatment of insomnia based on network pharmacology
10.3760/cma.j.cn115398-20190530-00201
- VernacularTitle:基于网络药理学探讨黄连阿胶汤治疗失眠症的作用机制
- Author:
Zhaoling LIN
1
;
Xiaoyan GU
;
Yue ZHONG
;
Mei HUANG
Author Information
1. 广州中医药大学第一临床医学院 510405
- From:
International Journal of Traditional Chinese Medicine
2020;42(3):256-263
- CountryChina
- Language:Chinese
-
Abstract:
Objective:By taking network pharmacology approach to search for active components and the rapeutic targets of Huanglian-Ejiao Decoction. Methods:According to the pharmacokinetic parameters, this research screened components of this decoction, and diged the drugs and disease targets with network pharmacology and constructed the drug-target-pathway network by Cytoscape system to investigate the mechanism of Huanglian-Ejiao Decoction. Results:It was found that 19 components such as hydroberberine, β-sitosterol, curcumin, kaempferol, berberine and Ramie flavonoids in Huanglian-Ejiao Decoction could take effecton insomnia by regulating 25 targets such as 5-hydroxytryptamine, dopamine, gamma aminobutyric acid, opioid receptor and acetylcholine. Conclusion:Huanglian-Ejiao Decoction may play an important role in treating insomnia by regulating multiple-targets.
