Genetic susceptibility genes of childhood moyamoya disease
10.3760/cma.j.issn.1673-4408.2020.07.007
- VernacularTitle:儿童烟雾病遗传易患基因研究进展
- Author:
Yao WANG
1
;
Zhihong ZHUO
Author Information
1. 郑州大学第一附属医院儿科 450052
- From:
International Journal of Pediatrics
2020;47(7):468-471
- CountryChina
- Language:Chinese
-
Abstract:
Moyamoya disease(MMD) is a chronic progressive cerebrovascular disease characterized by progressive stenosis or occlusion of bilateral infernal of internal carotid artery, initial segments of anterior cerebral artery and middle cerebral artery and abnormal vascular network formation accompanied by compensatory hyperplasia of skull base.With the development of neuroimaging technology, the report of the disease has a rising trend year by year, the etiology and pathogenesis of MMD have not been clarified yet.Because of its racial susceptibility and familial aggregation, it is believed that genetic factors may be involved in the pathogenesis.This article mainly reviews the genetic related genes of MMD, aiming at understanding the role of genetic related genes in the occurrence and development of MMD in detail and comprehensively so as to make diagnosis earlier and more accurately, which is helpful for timely treatment and improvement of long-term prognosis for children.
