18F-FDG PET/CT evaluation on correlation between metabolic activity and immunophenotype of newly diagnosed T cell lymphoma

VernacularTitle: 18F-FDG PET/CT评价初诊T细胞淋巴瘤代谢活性与免疫表型的相关性
Author: Jing ZHAO ¹
Author Information

1. Department of Nuclear Medicine, Peking University First Hospital
Publication Type:Journal Article
Keywords: Fluorodeoxyglucose F18; Immunophenotypes; Lymphoma, T-cell; Positron-emission tomography; Tomography, X-ray computed
From: Chinese Journal of Interventional Imaging and Therapy 2020;17(8):474-478
CountryChina
Language:Chinese
Abstract: Objective: To explore the relationship between metabolic activity on 18F-FDG and immunophenotype of newly diagnosed T cell lymphoma. Methods: Data of 64 cases of newly diagnosed T cell lymphoma confirmed by pathology were retrospectively analyzed. All patients underwent PET/CT examination, and the detailed immunohistochemical results were obtained. ROI were drawn on PET/CT, and the maximum standardized uptake value (SUVmax) of biopsy site was measured. The correlation between SUVmax and immunophenotype was analyzed. Results: The median SUVmax at biopsy-proven malignant lesions in 64 cases was 8.02 (2.23-24.42). SUVmax of lesions was positively correlated with expression of Ki-67 and CD5 (rs=0.31, P=0.02; rs=0.81, P<0.01), but not with other immunological factors (all P>0.05). Conclusion: The metabolic activity of T cell lymphoma lesions on 18F-FDG are related to the expression of Ki-67 and CD5. 18F-FDG can be used as an imaging method for noninvasive evaluation on expression of Ki-67 and CD5.