Genetic Study of Inflammatory Bowel Disease and its Clinical Application
10.3969/j.issn.1008-7125.2019.01.001
- Author:
Zhanju LIU
1
Author Information
1. Department of Gastroenterology, The Tenth People's Hospital of Tongji University
- Publication Type:Journal Article
- Keywords:
Clinical Application;
Genetic Predisposition to Disease;
Inflammatory Bowel Disease;
Susceptibility Genes
- From:
Chinese Journal of Gastroenterology
2019;24(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is an idiopathic and chronic non-specific inflammatory disease of gastrointestinal tract. Abnormal immune response in intestinal mucosa toward commensal microbiota together with intestinal mucosal barrier defects, genetic and environmental factors might be associated with the pathogenesis of human IBD. In recent years, great progress has been made in genetic study of IBD, providing important help for clinical translation and application. Genetic analysis will help us to explain the etiology and lesional areas of IBD, predict the disease behaviors and effectiveness of treatment, thereby benefits the clinical diagnosis and treatment of the disease. This review summarizes the latest achievements and new progresses in genetic study and clarifies the potential value of genetic study in management of IBD.
