Correlation of Coagulation Disorders With Disease Activity in Patients With Crohn's Disease
10.3969/j.issn.1008-7125.2019.04.008
- Author:
Qi JIANG
1
Author Information
1. Department of Gastroenterology, Ningbo First Hospital
- Publication Type:Journal Article
- Keywords:
Blood Coagulation;
Crohn Disease;
Fibrinolysis;
Therapy
- From:
Chinese Journal of Gastroenterology
2019;24(4):224-229
- CountryChina
- Language:Chinese
-
Abstract:
Patients with Crohn's disease (CD) are in hypercoagulable state and are susceptible to thromboembolic events. Aims: To investigate the correlation of coagulation disorders with disease activity and phenotype of patients with CD. Methods: A cohort of 108 newly diagnosed active CD patients from Jan. 2015 to Dec. 2017 at the Ningbo First Hospital were enrolled and compared with 55 healthy controls for coagulation and fibrinolysis status. Correlations between the altered coagulation indicators, platelet counts and the CD activity index (CDAI), simple endoscopic score for CD (SES-CD) were analyzed. Furthermore, stratification analysis was performed according to the disease activity, Montreal classification, and time points before and after individualized treatment. Results: The fibrinogen (FIB), activated partial thromboplastin time (APTT) and platelet counts were significantly higher in CD patients than in controls (P<0.05), and were elevated from mild, moderate to severe CD (P<0.05), while the prothrombin activity (PTA) was significantly lower in CD patients and decreased with the disease severity (P<0.05). Pearson correlation coefficient analysis revealed positive correlations between CDAI, SES-CD and FIB, APTT, platelet counts (P<0.05), as well as negative correlations between CDAI, SES-CD and PTA (P<0.05). Stratification analysis for Montreal classification showed the FIB, APTT and platelet counts in patients with phenotype B3 were significantly higher than those with phenotype B1 (P<0.05), whereas the PTA in phenotype B3 was significantly lower (P<0.05). After treatment with biological agents, all the abovementioned indicators improved with varied degrees, especially PTA and platelet counts. Conclusions: Abnormal activation of coagulation and fibrinolysis occurs in CD patients, and is correlated with disease activity and penetrating phenotype. PTA might be a promising predictor for disease activity of CD.
