Relationship Between Components of Metabolic Syndrome and Clinicopathological Characteristics of Colorectal Adenoma
10.3969/j.issn.1008-7125.2019.06.007
- Author:
Xue LI
1
Author Information
1. Endoscopy Center, Inner Mongolia Autonomous Region People's Hospital
- Publication Type:Journal Article
- Keywords:
Clinicopathological Characteristics;
Colorectal Adenoma;
Metabolic Syndrome X;
Risk Factors
- From:
Chinese Journal of Gastroenterology
2019;24(6):350-354
- CountryChina
- Language:Chinese
-
Abstract:
Background: Colorectal cancer (CRC) is one of the most common malignant tumors in digestive system. Colorectal adenoma (CRA) is recognized as a precancerous lesion of CRC. Therefore, it is of great significance to find the risk factors of CRA for the prevention of CRC. Aims: To investigate the relationship between components of metabolic syndrome (MS) and clinicopathological characteristics of CRA. Methods: A total of 460 patients with CRA from December 2014 to December 2016 at the Affiliated Hospital of Inner Mongolia Medical University were enrolled. Components of MS and clinicopathological characteristics were recorded. Correlation of MS with clinicopathological characteristics of CRA were analyzed by χ2 test or Spearman's rank correlation. Influencing factors of clinicopathological characteristics of CRA were analyzed by multivariate Logistic regression analysis. Results: MS was related to pathological type, pedicle, and size of CRA (P<0.001, rp=0.317; P<0.001, rp=0.321; P=0.001, rs=0.150), but not related to location and number of CRA (P>0.05). Hypertension, diabetes, high triglyceride (TG), high waistline increased the risk of villous adenoma (P<0.05), while age, high waistline increased the risk of tubulovillous adenoma (P<0.05). Hypertension, high TG, high waistline increased the risk of CRA pedicle (P<0.05). Age increased the risk of CRA in the whole colon (P<0.05), however, gender, hypertension, diabetes, high TG, low HDL, high waistline had no significant influence on CRA in proximal colon and whole colon (P>0.05). Diabetes, high waistline were the risk factors of size of CRA (P<0.05). Gender, age, hypertension, diabetes, high TG, low HDL, high waistline were not related to the number of CRA (P>0.05). Conclusions: MS is correlated with pathological type, pedicle, and size of CRA. Hypertension, diabetes, high TG, high waistline are the risk factors of villous adenoma; while age, high waistline are the risk factors of tubulovillous adenoma. Hypertension, high TG, high waistline are the risk factors for CRA with pedicle. Age is the risk factor for CRA in the whole colon. Diabetes, high waistline are the risk factors for size of CRA.
