Diagnosis and Differential Diagnosis of Drug-induced Liver Injury: A Challenge in Clinical Practice
10.3969/j.issn.1008-7125.2019.10.002
- Author:
Yimin MAO
1
Author Information
1. Division of Gastroenterology and Hepatology, School of Medicine, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Diagnosis, Differential;
Drug-Induced Liver Injury
- From:
Chinese Journal of Gastroenterology
2019;24(10):581-585
- CountryChina
- Language:Chinese
-
Abstract:
Diagnosis and differential diagnosis of drug-induced liver injury (DILI) is still a challenge in clinical practice due to lack of specific diagnostic biomarkers and the fact that drugs can cause all known types of liver injuries. Currently, the diagnosis of DILI is still based on an exclusive strategy. The Roussel Uclaf Causality Assessment Method (RUCAM) has been recommended by major guidelines as a standard method for assessing DILI causality in clinical practice. However, due to the defects of RUCAM and the complex clinical phenotypes of DILI, it is still unable to fully meet the needs of complex clinical problems. Therefore, further research should focus on development of new assessment scales and specific diagnostic biomarkers.
