Mechanism of Effect of Ubiquitination Modification Mediated by E3 Ubiquitin Ligase in Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2020.04.013
- VernacularTitle: E3泛素连接酶介导泛素化修饰在炎症性肠病中的作用机制研究
- Author:
Dan ZHANG
1
Author Information
1. Shanghai Research Institute of Acupuncture and Meridian
- Publication Type:Journal Article
- Keywords:
E3 Ubiquitin Ligase;
Inflammatory Bowel Disease;
Mechanism;
Ubiquitination Modification
- From:
Chinese Journal of Gastroenterology
2020;25(4):250-253
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitination is the important type of post-translational modification of proteins, and its main effects include protein degradation and functional regulation. Studies have shown that abnormal ubiquitination is involved in the development and progress of inflammatory bowel disease (IBD), which makes some ubiquitinases and their antibodies having the potential to be important markers for clinical diagnosis and evaluation of severity of Crohn's disease (CD). This article reviewed the research on mechanism of effect of ubiquitination modification mediated by E3 ubiquitin ligase in IBD.
