One-stop pancreas perfusion CT combined with enhancement in evaluation on pancreatic neuroendocrine neoplasms
10.13929/j.issn.1003-3289.2020.01.026
- Author:
Hui HAO
1
Author Information
1. Department of Radiology, The First Affiliated Hospital of Zhengzhou University
- Publication Type:Journal Article
- Keywords:
Carcinoma, pancreatic ductal;
Perfusion imaging;
Tomography, X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2020;36(1):91-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the value of one-stop pancreas perfusion CT combined with enhancement in evaluation on pancreatic neuroendocrine neoplasms (pNEN). Methods: A total of 30 patients with histopathologically proved pNEN who underwent one-stop pancreas perfusion CT combined with enhancement scan were collected. Imaging features of pNEN were analyzed, the perfusion parameters (blood volume [BV], blood flow [BF], mean transit time [MTT] and capillary surface permeability [PS]) and tissue time density curve (TDC) were observed, the perfusion parameters were compared between different grades of tumors, and the efficacy of radiation dose was analyzed. Results: Pseudo-color images showed that compared with surrounding pancreatic tissue, significantly higher-perfusion was observed in pNEN tissue, with BV of (22.80±6.42)ml/100 g, BF of (237.38±134.86)ml/(min·100 g),significantly higher than those of surrounding pancreatic tissue (both P<0.05). MTT of pNEN tissue was (7.03±3.48)s, PS was(3.25±1.99)ml/(min·100 g), both lower than surrounding pancreatic tissue (both P<0.05). The developing time of pNEN lesion was approximately 19.42-24.14 s. TDC showed a rapid ascending trend and then rapid decreasing to the plateau in pNEN tissue, whereas a slowly increasing to the peak value and then a slight decrease to the plateau in the normal tissue. According to histopathological grades, pNEN were divided into groups A(G1) and B(G2/G3).PS values of group A ([4.48±2.21]ml/[min·100 g-]) and B ([2.23±1.34]ml/[min·100 g]) were significantly different (P<0.05), while BV, BF and MTT values were not (all P>0.05). There was negative correlation between PS and tumor grade (r=-0.52, P<0.01). The total X-ray dose of whole scan was (19.88±3.03)mSv. Conclusion: One-stop pancreas perfusion CT combined with enhancement scan can diagnose pNEN according to morphological features and perfusion parameters with small radiation dose, and PS parameters may distinguish pNEN grading preoperation. One-stop pancreas perfusion CT combined with enhancement scan is helpful to choice of optimal scanning time of suspicious pNEN lesions during conventional enhanced CT.
