Brain white matter changes and correlations with cognition in end-stage renal disease patients with secondary hyperparathyroidism based on local diffusion homogeneity values
10.13929/j.issn.1003-3289.2020.01.010
- Author:
Hanqiu WU
1
Author Information
1. Department of Radiology, The Second Hospital of Anhui Medical University
- Publication Type:Journal Article
- Keywords:
Cognition;
Hyperparathyroidism, secondary;
Kidney failure, chronic
- From:
Chinese Journal of Medical Imaging Technology
2020;36(1):37-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the changes of white matter in patients of end-stage renal disease (ESRD) with secondary hyperparathyroidism (SHPT) by using local diffusion homogeneity (LDH). Methods: Fifty patients diagnosed as ESRD and underwent hemodialysis were selected. According to whether with SHPT or not, the patients were divided into SHPT group and non-SHPT group (each n=25). The cognitive function was evaluated with Montreal cognitive assessment (MoCA). Then MR plain scan was performed. The LDH value of white matter fiber in the whole brain were compared between 2 groups based on voxel. Results: Compared with non-SHPT group, SHPT group showed diffuse and symmetrical LDH decreased area in bilateral cerebral hemispheres, and in the focal right cerebellar hemispheres (all P<0.01). The areas with increased LDH value were mainly in brainstem and cerebellum (P<0.01). In SHPT group, the total score of MoCA was negatively correlated with the level of iPTH (r=-0.525), positively correlated with the level of education (r=0.413). The total score of MoCA was positively correlated with LDH value of left corticospinal tract (r=0.500, all P<0.05), while the level of iPTH was not correlated with the LDH value of different brain regions in SHPT group (all P>0.05). Conclusion: LDH value can provide information of the white matter's LDH in ESRD patients with SHPT, and the changes are related to cognition and clinical indicators.
