Evaluation of rat nonalcoholic fatty liver based on multi-echo liver interpolated volume excitation imaging
10.13929/j.issn.1003-3289.2020.01.007
- Author:
Jia WANG
1
Author Information
1. Department of Radiology, The First Affiliated Hospital of Soochow University
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Nonalcoholic fatty liver disease;
Rat
- From:
Chinese Journal of Medical Imaging Technology
2020;36(1):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the value of MR multi- echo liver interpolated volume excitation image (mLIVE) in diagnosis of rat nonalcoholic fatty liver. Methods: Totally 64 female SD rats were selected and randomly divided into experiment group (n=40) and control group (n=24). Rats in experimental group were fed high-fat diet, while those in control group were fed normal diet. Five experimental and 3 control rats were selected for liver MR examination, histopathological examination and liver fat content determination every week after 4 weeks, respectively. Then the results of live fat fraction (FF) obtained with mLIVE imaging, pathological and fat contents of the 2 groups were compared. Results: The average FF value of control and experiment group was (5.67±0.69)% and (10.48±3.24)%, respectively (P<0.05).In experimental group, there were 11 rats with mild fatty liver, 16 with moderate fatty liver and 9 with severe fatty liver. The average FF value of different state of fatty liver in experiment group were (7.99±1.48)%, (10.38±1.70)% and (13.71±4.33)%, respectively (P<0.05). The average liver fat contents of 2 groups was (18.83±6.29)nmol/mg and (50.44±20.24)nmol/mg, respectively (P<0.05). There was positive correlation between liver FF and liver fat contents (r=0.74, P<0.001), and the linear regression equation was y=4.22+0.13x. Conclusion: MR mLIVE imaging can be used for quantitative analysis of liver fat, and therefore the evaluation of fatty liver.
