Ultrasonic elastic characteristics of breast cancers with different molecular subtype
10.13929/j.issn.1003-3289.2020.07.017
- VernacularTitle: 不同分子分型乳腺癌超声弹性特征
- Author:
Fang WU
1
Author Information
1. Department of Function, The First Affiliated Hospital of Shihezi University School of Medicine
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Molecular subtype;
Virtual touch tissue imaging quantification technique
- From:
Chinese Journal of Medical Imaging Technology
2020;36(7):1017-1021
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe elastic features of breast cancer with different molecular subtype using virtual touch tissue imaging quantification (VTIQ) technique. Methods: Totally 101 patients with pathologically proven breast cancers were collected. All patients underwent preoperative routine ultrasound and VTIQ examination. The elastic features and the maximum shear wave velocity (SWVmax) were obtained with VTIQ technique, and the molecular subtypes of breast cancers were recorded according to pathological findings after surgical resection. The elastic features and SWVmax of different molecular subtype breast cancer were analyzed. Results: The predominant elastic model of Luminal tumor was edge advantage, of human epidermal growth factor receptor-2epidermal growth factor 2 (HER-2) expression type tumor was center advantage, while of triple-negative type tumor was homogeneity (P<0.05). Significant differences of SWVmax in marginal region of breast cancers were found among different molecular subtypes (P<0.05), the order of SWVmax of tumor margin was in turn: Luminal A type>Luminal B type>HER-2 expression type>triple-negative type. No significant difference of SWVmax in central region of breast cancer was observed among different molecular subtypes (P>0.05), nor of SWVmax in tumor surrounding tissue (P>0.05). Conclusion: The elastic features and SWVmax, especially in the marginal regions of breast cancers are related with molecular subtype,which may reflect the biological characteristics of breast cancer on certain degree. VTIQ may be helpful to treatment planning and evaluation on prognosis of breast cancer.
