Resting state fMRI observation on effect of transcranial direct current stimulation on cortical connectivity dysfunction of posterior cingulate cortex in young volunteers after sleep deprivation
10.13929/j.issn.1003-3289.2020.08.010
- VernacularTitle: 静息态fMRI观察经颅电刺激对睡眠剥夺后青年志愿者后扣带回皮质连接紊乱的干预作用
- Author:
Ning ZHANG
1
Author Information
1. Department of MRI, Beijing Shijitan Hospital, Capital Medical University
- Publication Type:Journal Article
- Keywords:
Gyrus cingula;
Magnetic resonance imaging;
Sleep deprivation;
Transcranial direct current stimulation
- From:
Chinese Journal of Medical Imaging Technology
2020;36(8):1163-1167
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of transcranial direct current stimulation (tDCS) on dysfunction of bilateral posterior cingulate cortex (PCC) in young volunteers after sleep deprivation (SD) with resting state functional MRI (rs-fMRI). Methods: Totally 16 healthy subjects who underwent 24 h SD twice at intervals were randomly given tDCS/sham tDCS SD. fMRI data and Montreal cognitive assessment (MoCA) scores were collected after rest wakefulness (RW), SD and tDCS, respectively. Bilateral PCC were selected as the seed points to calculate the functional connection between the seed points and the whole brain. The changes of functional connection between the above three time points and tDCS/sham tDCS were observed, and the differences of MoCA scores were compared. Results: The mean score of MoCA in SD subjects was lower than that in RW (t=8.047, P<0.05), while the mean score of MoCA after tDCS was higher (27.06±1.53) than that after sham tDCS (25.13±1.86, t=-3.081, P=0.008) and 24 h SD (24.75±2.41, t=3.306, P=0.005). Compared with RW, functional connection between PCC and thalamus increased, while between PCC and right anterior cuneiform lobe decreased. Compared with that after tDCS, functional connection in bilateral thalamus decreased after tDCS, whereas in the left PCC and the right anterior cuneiform lobe increased. Conclusion: 24 h SD can cause extensive connectivity dysfunction of PCC network. tDCS has certain regulatory effect on the network functional connectivity disorders caused by SD.
