Quantitative assessment of fetal brain volume with MRI
10.13929/j.issn.1003-3289.2020.08.001
- VernacularTitle: MRI定量评估胎儿脑体积
- Author:
Jingya REN
1
Author Information
1. Department of Radiology, Shanghai Childern's Medical Center, Shanghai Jiaotong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Brain;
Fetus;
Magnetic resonance imaging;
Volume
- From:
Chinese Journal of Medical Imaging Technology
2020;36(8):1121-1126
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the value of MRI quantitative brain volume in evaluating fetal brain development. Methods: A total of 60 single pregnant women with 21-37 weeks of gestation without central system lesion or dysplasia underwent fetal single-shot turbo spin echo (SSTSE) sequence MR scanning. The fetal brain images were post-processed, and then fetal three-dimensional brain volume indicators, including intracranial cavity volume (ICV), total brain volume (TBV) and cerebrospinal fluid volume (CFV) were manually measured. Meanwhile, two-dimensional diameter indexes of brain,i.e. brain biparietal diameter (BPD), skull biparietal diameter (SBD), skull fronto-occipitoal diameter (SOD) and head circumference (HC) were measured and calculated. The correlation of two-dimensional diameter indexes and three-dimensional brain volume indicators with gestational age (GA) were analyzed, and the corresponding regression analysis was carried out, respectively. The relationships between three-dimensional brain volume indicators and two-dimensional diametric indexes were analyzed. Results: TBV (r=0.98), ICV (r=0.97), CFV (r=0.89), BPD (r=0.96), SBD (r=0.94), SOD (r=0.96) and HC (r=0.96) were all highly positively correlated with GA (all P<0.01), and the corresponding regression equations were obtained. There were high positive correlation among TBV, ICV and two-dimensional diametric indexes (all P<0.01)and strong correlation between HC and CFV (P<0.01). Conclusion: MRI three-dimensional quantitative brain volume can be used to evaluate fetal brain development at 21-37 weeks of gestation, providing a new imaging method for prenatal diagnosis of fetal brain disease and study of pathogenesis.
