Quantitative analysis of cerebral hemodynamics change in hypertensive patients with multiple inversion time-pulsed arterial spin labeling imaging
10.13929/j.issn.1003-3289.2020.10.003
- VernacularTitle: 多反转时间动脉自旋标记成像定量分析 高血压脑血流动力学改变
- Author:
Hui TAN
1
Author Information
1. School of Basic Medicine and Medical Technology, Shaanxi University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Brain;
Hemodynamics;
Hypertension;
Magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2020;36(10):1451-1455
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of multiple inversion time-pulsed arterial spin labeling (mTI-ASL) technique in quantitative analysis of change in cerebral hemodynamics changes in patients with different degrees of hypertension. Methods: Brain conventional MRI and mTI-ASL imaging of 55 hypertensive patients (hypertension group) and 20 age-matched healthy volunteers (control group) were collected. Hypertensive patients were divided into 3 subgroups: grade 1 subgroup (n=20), grade 2 subgroup (n=20) and grade 3 subgroup (n=15). The relative cerebral blood flow (rCBF) and arterial transit time (ATT) of gray matter (frontal lobe, temporal lobe and occipital lobe), white matter (bilateral centrum semiovale, anterior and posterior horns of paraventricular white matter, genu and spleniu of corpus callosum), basal ganglia and thalamus were obtained from mTI-ASL images, and the differences of rCBF and ATT values among the groups were compared. Results: Except for gray matter, the rCBF and ATT values of each brain region of hypertension grade 1 subgroup were lower than that of control group (all P<0.05). There was no significant difference in rCBF values of bilateral centrum semiovale and corpus callosum and ATT values of bilateral centrum semiovale between hypertension grade 1 subgroup and hypertension grade 2 subgroup (all P>0.05), but there were statistical differences in rCBF and ATT values of other brain regions (all P<0.05). Except for white matter of anterior and posterior horn of lateral ventricle, the rCBF and ATT values of other brain regions between hypertension grade 3 subgroup and hypertension grade 2 subgroup were statistical significant (all P<0.05). There were statistical differences in rCBF and ATT values in different brain regions among the other groups (all P<0.05). Conclusion: mTI-ASL imaging can quantitatively analyze the changes of cerebral hemodynamics in hypertensive patients, monitoring the progression of hypertension.
