Preparation of esomeprazole magnesium enteric-coated capsules
- Author:
Jun-Bo LUO
1
Author Information
- Publication Type:Journal Article
- Keywords: Enteric-coated pellet; Esomeprazole magnesium; Fluid bed coating technology; Multiple-unit pellet system
- From: Chinese Pharmaceutical Journal 2015;50(9):789-792
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To prepare and evaluate esomeprazole magnesium enteric-coated capsules which is compacted by multiple-unit pellet system (MUPS). METHODS: The esomeprazole magnesium enteric-coated pellets were prepared by fluid bed coating technology, and the effects of isolation layer, amont of core, and thickness of enteric-coated film on the quality of the product were e-valuated. RESULTS: The prepared esomeprazole magnesium enteric-coated capsules showed good release behavior in artificial gastric fluid. The dissolution in artificial intestinal fluid was rapid and complete. CONCLUSION: The established process of preparing esomeprazole magnesium enteric-coated pellets is feasible and reproducible, and the product has similar quality with the original preparation. It is expected to be used in the industrial production.
