Chemical Constituents from Stellera chamaejasme Linn.
- VernacularTitle: 瑞香狼毒化学成分研究
- Author:
Nuan ZHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Chemical constituent; First isolation; Stellera chamaejasme Linn.
- From: Chinese Pharmaceutical Journal 2020;55(10):799-805
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVE: To study the chemical constituents from the roots of Stellera chamaejasme Linn. METHODS: The 95% ethanol extract of the roots of Stellera chamaejasme Linn. was fractionalized by using petroleum ether, dichloromethane and ethyl acetate, respectively. The extraction parts were isolated by various chromatographic methods including silica gel, ODS column and preparative HPLC methods. Their structures were elucidated on the basis of spectroscopic data such as HR-ESI-MS and NMR. RESULTS: Seventeen compounds were isolated and identified as follows: naringenin (1), (-)-epiafzelechin (2), (+)-epiafzelechin (3), 2,6,2',6'-tetramethoxy-4,4'-bis (2,3-epoxy-1-hydroxypropyl) biphenyl (4), 8-hydroxypluviatolide (5), (-)-syringaresinol (6), prestegane B (7), 7-hydroxycoumarin (8), daphnoretin (9), 3-(2,4-dihydroxyphenyl) propanoic acid methyl ester (10), 3,4-dihydroxystyryl alcohol (11), 3-[(1E)-3-hydroxy-1-propen-1-yl]-2, 5-dimethoxyphenyl-β-D-glucopyranoside(12), Z-octadecyl caffeate (13), 1-glyceryl linolenate (14), glycerol monolinoleate (15), 2, 3-dihydroxypropyl-9-octadecenoate (16) and β-sitosterol (17). CONCLUSION: Compounds 1, 2, 4, 5, 9-15 are reported from the genus Stellera Linn. for the first time.
