Transplacental Transfer of Glyburide in the ex vivo Human Placenta Perfusion Model
- VernacularTitle: 基于人胎盘体外循环灌注模型的格列本脲胎盘透过性研究
- Author:
Hua HUANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Ex vivo human placenta perfusion model; Gestational diabetes mellitus; Glyburide; Pregnancy; Transplacental transfer
- From: Chinese Pharmaceutical Journal 2020;55(18):1535-1539
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVEP: To determine the ex vivo human placental transfer of glyburide from maternal circulation to the fetal circulation in Chinese Hans population. METHODS: Perfusion studies were performed on thirty-six placentas from healthy term pregnancies. The circulation of mother-placenta-fetus was set up ex vivo within minutes and accessed by studying spectrometry. Integrity and viability of the placenta were determined by measuring fetal volume loss, pH, pO2, ΔhCG, glucose consumption and lactate production during the perfusion experiments. RESULTS: Following 3 h of perfusion, the fetal transfer rate of glyburide was (1.64±0.85)%. The clearance index of glyburide was (0.05±0.03). CONCLUSION: These data suggest that tiny amount of glyburide can cross the human placenta. Glyburide could be used as a clinically effective alternative to insulin therapy.
