Relationship between Multidrug Resistance Gene ABCB1 C3435T Gene Polymorphism and Serum Concentration of Levetiracetam in Children with Epilepsy in Xinjiang
- VernacularTitle: ABCB1 C3435T基因多态性与新疆癫痫患儿左乙拉西坦血药浓度和临床疗效的相关性研究
- Author:
Ting ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: ABCB1 C3435T; Levetiracetam; Serum concentration
- From: Chinese Pharmaceutical Journal 2020;55(18):1530-1534
- CountryChina
- Language:Chinese
- Abstract: OBJECTIVEP: To explore the relationship between multidrug resistance gene ABCB1 C3435T gene polymorphism and serum concentration, clinical efficacy and adverse reactions of levetiracetam (LEV) in children with epilepsy in Xinjiang. METHODS: The serum concentration of 116 children with epilepsy of in Xinjiang were collected and determined by oral LEV. The ABCB1 C3435T genotype was detected by polymerase chain reaction-fluorescence staining in situ hybridization. The correlation between ABCB1 C3435T gene polymorphism and serum concentration, clinical efficacy and adverse reactions was analyzed. RESULTS: The C and T allele frequencies of ABCB1 C3435T in children were significantly different (χ2=12.520, P<0.01). The serum concentration of CC, CT and TT genotypes were 12.02, 13.74 and 14.53 μg•mL-1, respectively. The results of ANOVA showed that there were significant differences among the three groups (F=3.550,P<0.05). The serum concentration of LEV in children with epilepsy in Xinjiang with TT type was significantly higher than that of CC type and CT type. There was no significant difference in css between LEV effective group and ineffective group in CC type, CT type and TT type(P>0.05). The clinical effective rate of CT type was higher than that of CC type and TT type, and the incidence of adverse reactions of TT type was higher than that of CC type and CT type. There were significant differences in clinical efficacy and adverse reactions among CC type, CT type and TT type (χ2=12.870,P<0.01; χ2=19.292, P<0.01). CONCLUSION: ABCB1 C3435T gene polymorphism may has a effect on the serum concentration, clinical efficacy and adverse reactions of LEV in children with epilepsy in Xinjiang.
