Effect of L-NNA on GFAP production in the gerbil hippocampus after recirculation following ischemia
- Author:
Jing-Jun ZHANG
1
Author Information
1. Dept. of Neurology, Affiliated Hosp. Taishan Med. Coll.
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia;
Glial fibrillary acidic protein;
Hippocampus;
NG-nitro-L-arginine
- From:
Chinese Pharmacological Bulletin
2002;18(2):217-219
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of L-NNA on glial fibrillary acidic protein (GFAP) production in the gerbil hippocampus after recirculation following ischemia. METHODS: Both vessels occlusion and immunofluorescent methods in gerbil hippocampal tissue slices incubated in vitro were used. RESULTS: Recirculation following ischemia led to a rise on GFAP concentration in the hippocampus. GFAP positive cells mainly distributed in rediatum layer and molecullar layer in the hippocampus, L-NNA decreased GFAP synthesis. CONCLUSION: L-NNA is a strong inhibitor of nitric oxide synthase (NOS). It is possible that the role of endogenous NO mediated GFAP synthesis is inhibited by L-NNA.
