Research progress on roles of gut microbiota in cardiovascular disease and treatment
10.12092/j.issn.1009-2501.2020.07.017
- VernacularTitle: 肠道菌群在心血管疾病及治疗中的研究进展
- Author:
Yu YAN
1
Author Information
1. China-Japan Friendship Hospital
- Publication Type:Journal Article
- Keywords:
Cardiovascular disease;
Gut microbiota;
Individual treatment;
Therapeutic strategy
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(7):829-834
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease (CVD), a chronic disease endangering human health, remains the highest morbidity and mortality globally. The human gut is inhabited by communities of bacteria and viruses, along with their genome, are collectively known as the gut microbiota. Recent reserch suggests that gut microbiota affects various metabolic pathways in the host by producing and releasing important metabolites such as trimethylamine oxide, bile acids and short chain fatty acids, and play an important role in pathologies of CVD, such as atherosclerosis, hypertension, myocardial infarction, heart failure and dyslipidemia. Individual treatment based on gut microbiota, including diet intervention, fecal microbiota transplantation and small molecule antimicrobial enzyme therapeutics, may provide a potential novel strategy for therapeutics.
