Progress on TMPRSS2-ERG fusion gene product transcription regulation mechanism in prostate cancer cells
10.12092/j.issn.1009-2501.2020.07.011
- VernacularTitle: 前列腺癌细胞内TMPRSS2-ERG融合基因产物转录调控机制研究进展
- Author:
Ying CAO
1
Author Information
1. Center for Molecular Medicine, Zhejiang Academy of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Androgen receptors;
Notch pathways;
Prostate cancer;
Spotted zinc finger structural proteins;
TMPRSS2-ERG fusion gene
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(7):791-795
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is the most common malignant tumor in men in Europe and the United States, but the mechanism of prostate cancer occurrence and development is not completely clear. In prostate cancer, the TMPRSS2-ERG fusion gene has a high incidence, which promotes ERG overexpression and causes changes in target genes and signaling pathways, such as androgen receptors, spotted zinc finger structural proteins, Notch pathways. In-depth understanding of the transcriptional regulation mechanism of TMPRSS2-ERG fusion gene products in prostate cancer cells can provide new targets for drug action in the treatment of prostate cancer.
