Exploration and expectation on treatment strategies of central nervous system diseases based on transporters at blood-brain barrier
10.12092/j.issn.1009-2501.2020.08.015
- VernacularTitle: 基于血脑屏障转运体的中枢神经系统疾病治疗策略探讨与展望
- Author:
Kailong ZHONG
1
Author Information
1. Department of Pharmacy, Xiamen Branch, Zhongshan Hospital, Fudan University
- Publication Type:Journal Article
- Keywords:
Blood-brain barrier;
Central nervous system;
Drug delivery;
Transporters
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(8):953-960
- CountryChina
- Language:Chinese
-
Abstract:
The structural and functional integrity of the blood-brain barrier (BBB) is a prerequisite for the maintenance of the brain homeostasis and function. Because of the structural peculiarities of the BBB, macromolecules and hydrophilic substances can pass through it only by some BBB transporter-mediated mechanisms. At the same time, the BBB is also responsible for deportation of some endogenous or exogenous substances from the brain through the efflux transporters. The current research advances on some important transporters at the BBB closely related to central nervous system (CNS) drugs, have been summarized in this review. These transporters include ABC transporters, glucose transporters, transferring receptor, insulin receptor and so on. This review offers a overview of structures, functions, distributions, relationships with CNS disease and drugs and the factors influencing their expression of some transporters at the BBB. Clarifying these elements could make a big difference to promote the CNS drugs to reach the brain across the BBB. Moreover, it provides new insights for exploring pathogenic mechanisms of some CNS diseases and their treatment.
