Statins for primary prevention of atherosclerotic cardiovascular disease in people 75 years of age and older
10.12092/j.issn.1009-2501.2020.09.017
- VernacularTitle: 他汀在75岁及以上老人进行心血管疾病一级预防的现状
- Author:
Ming YANG
1
Author Information
1. Department of Geriatrics, Fujian Medical University Union Hospital
- Publication Type:Journal Article
- Keywords:
Atherosclerotic cardiovascular disease (ASCVD);
Primary prevention;
Statin;
The elderly
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2020;25(9):1074-1080
- CountryChina
- Language:Chinese
-
Abstract:
Statins are important drugs for the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). The role and status of statins in ASCVD secondary prevention have been established, but the application of statins in ASCVD primary prevention in the elderly is controversial, especially in the elderly aged 75 years and older. The evidence for primary prevention with statins is not adequate. It should be cautious to initiate statins for primary prevention, because of the frailty, multicomobidity, polypharmacy and the limited life expectancy of the elderly may increase the risk of statins adverse reactions. The recent clinical studies and guidelines of statin primary prevention in the elderly population especially in aged 75 years and older have been reviewed in the paper. Making decisions based on fully evaluating the patients' ratio of benefits and risk with patients and implement statin individualized treatment strategies are emphasized.
