Pharmacologic mechanism for protective effects of danshensu on cardiovascular system
10.7501/j.issn.0253-2670.2014.17.027
- Author:
Bing-Yao WANG
1
Author Information
1. State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Cardiovascular;
Danshensu;
Ischemia reperfusion injury;
Myocardial infarction
- From:
Chinese Traditional and Herbal Drugs
2014;45(17):2571-2575
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease is becoming the leading cause of death in the world. Salvia miltiorrhiza has a history of thousands of years in clinical therapy in China, which is widely used in the treatment of coronary heart disease, myocardial infarction, blood circulation diseases, and other cardiovascular diseases. More and more studies show that danshensu, the main water-soluble component in S. miltiorrhiza, has a variety of pharmacological effects, including inflammation and tumor inhibition, neuro and myocardial protection, immunity improving, and so on. With further research, the mechanisms of these pharmacological effects have been gradually clear. In this paper, we focus on the mechanism of danshensu on cardiovascular protection and provide a theoretical basis for the further study and clinical application of danshensu. The aspects of mechanism include inhibition on ischemia/reperfusion injury, hypertension, myocardial infarction, atherosclerosis, high cholesterol, and hypertension, protection of endothelial cells, and so on.
