Optimization of self-microemulsifying drug delivery system of naringenin by Box-Behnken design and response surface method
10.7501/j.issn.0253-2670.2014.17.008
- Author:
Zhang-Jie WANG
1
Author Information
1. School of Pharmaceutical Sciences, Anhui Xinhua College
- Publication Type:Journal Article
- Keywords:
Box-Behnken design and response method;
Drug loading;
Naringenin;
Particle size;
Self-microemulsifying drug delivery system;
Solubility
- From:
Chinese Traditional and Herbal Drugs
2014;45(17):2461-2466
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the formula of self-microemulsifying drug delivery system (SMEDDS) for naringenin. Methods: The solubility test of naringenin in different secondary solvents and pseudotemary phase diagam was utilized to select components of naringenin SMEDDS. According to the drug loading and particle size of naringenin in different self-microemulsifying drug prescriptions, the optimal prescription was determined using the Box-Behnken design and response surface method. Results: The optimal prescription of naringenin SMEDDS was composed of Ethyloleate (oil), Polysorbate 80 (surfactant), and PEG 400 (co-surfactant), with a weight ratio of 14.02:44.36:30. The drug loading of naringenin was 347.167 mg/g, and particle size was 38.21 nm in the optimal prescription. Conclusion: It is effective and practical to use Box-Behnken design and response method for optimizing the naringenin SMEDDS.
