Chemical constituents from Ampelopsis cantoniensis and their anti-angiogenic activities
10.7501/j.issn.0253-2670.2014.07.002
- Author:
Jian-Guo WEI
1
Author Information
1. Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences
- Publication Type:Journal Article
- Keywords:
Ampelopsis cantoniensis (Hook. et Arn.) Planch.;
Ampelopsis Michaux;
Anti-angiogenic activity;
Cantonienol;
Flavonoids;
Resveratrol;
Sesquiterpenes
- From:
Chinese Traditional and Herbal Drugs
2014;45(7):900-905
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from Ampelopsis cantoniensis and their anti-angiogenic activities. Methods: The compounds were isolated and purified by various chromatographic techniques and their structures were elucidated by spectral analysis. The anti-angiogenic activities of the compounds isolated were evaluated using a zebrafish model. Results: Fifteen compounds were obtained from the ethyl acetate fraction in the 90% ethanol extract of A. cantoniensis and their structures were identified as cantonienol (1), nootkatone (2), aromadendrane-4β, 10β-diol (3), abscisic acid (4), 12-oxo-hardwickiic acid (5), betulinic acid (6), platanic acid (7), vanillic acid (8), resveratrol (9), nectandrin B (10), nectandrin A (11), 3, 5, 7-trihydroxychromone (12), 5, 7, 3', 4', 5'-pentahydroxyflavanone (13), taxifolin (14), and myricitrin (15). Conclusion: Compound 1 is a new sesquiterpene named cantonienol. Compounds 2-7 and 10-12 are isolated from the plants of Ampelopsis Michaux for the first time, and the other compounds are firstly reported in this plant. Compounds 9, 11, and 12 exhibit the weak anti-angiogenic activity when evaluated using a zebrafish model.
