Effect of microcrystalline cellulose on compressibility and moldability of Galla chinensis extract
10.7501/j.issn.0253-2670.2014.08.007
- Author:
Han-Han CAO
1
Author Information
1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Compressibility;
Direct compression tableting;
Galla chinensis extract;
Microcrystalline cellulose;
Moldability
- From:
Chinese Traditional and Herbal Drugs
2014;45(8):1072-1077
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of microcrystalline cellulose (MCC) on compressibility and moldability of Galla chinensis extract (GCE). Methods: Four types of MCC were chosen and mixed with GCE respectively in different proportions. The powder was tabletted by Korsch XP-1 Intelligent Induction Tablet Machine, and the compressibility and moldability were evaluated using plasticity constant, elastic recovery, compression ratio, yield pressure, tensile strength, and their change rules as indexes. Results: The compressibility and moldability of GCE were poor. CeolusKG802 was the best at improving elastic recovery and compression ratio among the four kinds of MCC. AvicelDG improved the plasticity constant and tensile strength most when the adding amount was low, and CeolusKG802 improved them most when the adding amount was high. To yield pressure, CeolusKG802 exhibited greater reduction than the other MCC when added in a low amount. As for a high amount, the result was opposite. Conclusion: MCC has good compressibility and moldability in the compression process; Different types of MCC have different advantages. The change law of compression parameters is obtained by investigating the compression of mixed powders of MCC with different proportions on GCE.
