Preparation of osmotic pump tablets ginsenoside Rg3 of solid dispersion and its release characteristic in vitro
10.7501/j.issn.0253-2670.2014.11.012
- Author:
Chao WU
1
Author Information
1. College of Pharmacy, Liaoning Medical University
- Publication Type:Journal Article
- Keywords:
In vitro dissolution;
Mono-layer osmotic pump tablets;
Osmotic pump;
Solid dispersion;
Two-layer osmotic pump tablets
- From:
Chinese Traditional and Herbal Drugs
2014;45(11):1561-1565
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the differences on release behaviors between the mono-layer and two-layer osmotic pump tablets of ginsenoside Rg3 solid dispersion and to find out the advantages and disadvantages of each preparation. Methods: The mono-layer and two-layer osmotic pump tablets of ginsenoside Rg3 solid dispersion were prepared and the prescription optimization was examined by comparing the in vitro release behaviors such as type and amount of the osmotic active substances, amount of suspending agent, amount of porogen in the coating solution, and thickness of the coating. Results: Mono-layer and two-layer osmotic pump tablets were well accorded with the zero-order equation. Fitting with the zero-order release model, the coefficients of the mono-layer and two-layer osmotic pump tablets were r1=0.998 1 and r2=0.990 6, respectively. Conclusion: Two-layer Rg3 osmotic pump tablets could release more completely than mono-layer osmotic pump tablets, but have more complex preparation process.
