Analysis on in vivo metabolites of α-hederin in rats by UPLC-MS/MS
10.7501/j.issn.0253-2670.2014.13.014
- Author:
Qi-Dong LIANG
1
Author Information
1. Jiangxi University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Deglycosylation;
Demethylation;
Glucuronidation;
Metabolites;
UPLC-Q/Trap- MS;
α-hederin
- From:
Chinese Traditional and Herbal Drugs
2014;45(13):1883-1888
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the metabolites of α-hederin in feces of rats after ig administration. Methods: An UPLC-Q/Trap-MS method was used for the identification of metabolites of α-hederin in feces of rats after ig administration of α-hederin (150 mg/kg). Results: Seven metabolites were detected in rat feces, including demethylation of α-hederin (M1), 3-O-α-L-arabinopyranoside hederagenin (M2), hederagenin (M3), glucuronideconjugate of α-hederin (M4), and double bond bonus of α-hederin (M5, M6-1, and M6-2). Conclusion: α-Hederin experiences a variety of metabolic reactions in rat gastrointestinal tract, mainly including deglycosylation, glucuronidation, demethylation, etc.
