Preparation and quality evaluation of chrysophanol proliposomes
10.7501/j.issn.0253-2670.2014.14.010
- Author:
Li-Hua WANG
1
Author Information
1. Institute of Applied Chemistry, Hebei North University
- Publication Type:Journal Article
- Keywords:
Carrier aggradation method;
Chrysophanol;
Entrapment efficiency;
Preparation;
Proliposome;
Quality evaluation
- From:
Chinese Traditional and Herbal Drugs
2014;45(14):2014-2017
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study and evaluate the quality of chrysophanol proliposomes. Methods: Chrysophanol proliposomes were prepared by carrier aggradation method. A single-factor investigation and orthogonal design were used to optimize the formulation by entrapment efficiency (EE). And the stability, shape, and size were observed. Results: The optimum prescription of chrysophanol proliposomes as follows: the temperature was 40°C, the ratio of carrier-phospholipid was 40:1, the ratio of cholesterol-phospholipid was 1:5, and the ratio of phospholipid-drug was 1:12. Chrysophanol proliposomes prepared by the result of the orthogonal design showed the uniform particle and good stability with the EE up to (84.69 ± 2.29)%, the particle size was (593.4 ± 14.2) nm, and the Zeta potential was (-54.35 ± 0.88) mV. Conclusion: The proliposomes prepared by the carrier aggradation method are used by sorbitol to get high EE, stability and uniform particle size to optimize the prescription and preparation conditions.
