Optimization of damp-proof excipients for Gushuling Granules
10.7501/j.issn.0253-2670.2014.14.008
- Author:
Yu-Lin ZHU
1
Author Information
1. Department of Pharmacy, First Affiliated Hospital of Bengbu Medical College
- Publication Type:Journal Article
- Keywords:
Angle of repose;
Damp-proof excipients;
Formability;
Gushuling Granules;
Hygroscopicity;
Lactose;
Mannitol
- From:
Chinese Traditional and Herbal Drugs
2014;45(14):2005-2008
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the effect of the excipients on hygroscopicity of Gushuling Granules and optimize the damp-proof excipients. Methods: Moisture absorption rate was used to optimize the type and ratio of materials; The concentration of ethanol, moisture absorption rate, formability, angle of repose, and appearance of Gushuling Granules were used to optimize the molding technology. Results: The best damp-proofing excipients were as follows: the hybrid materials were lactose-mannitol 4:1, medicine-auxiliary ratio of 1:2, and with 85% ethanol to granulate. Gushuling Granules were good uniform, damp-proofing, and formability, the critical relative humidity was 76%. Conclusion: The preparation technology is stable. The study provides the experimental evidences for the research and development of Gushuling Granules.
