Promotion of suet oil to absorption and transportation of total flavonoids from Epimedii Folium
10.7501/j.issn.0253-2670.2015.16.017
- Author:
Jie LI
1
Author Information
1. Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Caco-2 cell monolayer model;
Icariin;
In vivo intestinal perfusion model of rats;
Permeability coefficients;
Self-assembled micelles;
Suet oil;
Total flavonoids from Epimedii Folium
- From:
Chinese Traditional and Herbal Drugs
2015;46(16):2439-2444
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the promotion mechanism of suet oil to the intestinal absorption of the total flavonoids from Epimedii Folium (EF). Methods: The in vivo intestinal perfusion model and Caco-2 cell monolayer model of rats were used to study the influence of processing excipient suet oil in self-assembled micelles on the intestinal absorption of total flavones from EF. Results: In the in vivo intestinal perfusion model of rats, there were differences of absorption of icariin in the total flavonoids from EF in the four segments of the intestines. After the suet oil was added and self-assembled micelles were formed, the permeabilities of icariin in the total flavonoids from EF were increased significantly in duodenum and jejunum segments. In Caco-2 cell monolayer model of rats, the absorptive permeability coefficients were small for icariin in the total flavonoids from EF, after the suet oil was added and the self-assembled micelles were formed, the absorptive permeability coefficients were increased significantly, the efflux ratios were decreased from 4.72 to 2.31. Conclusion: The total flavonoids from EF have a bad intestinal absorption, after the suet oil added and the self-assembled micelles formed, the intestinal absorption of the total flavonoids from EF could be improved.
