Application of QAMS method in quantitative evaluation of Liuwei Dihuang Soft Capsule
10.7501/j.issn.0253-2670.2015.19.011
- Author:
Wei SHI
1
Author Information
1. Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Liuwei Dihuang Soft Capsule;
Loganin;
Quality evaluation;
Quantitative analysis of multi-components by single marker;
Relative correction factor
- From:
Chinese Traditional and Herbal Drugs
2015;46(19):2880-2886
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish a quantitative analysis of multi-components by single marker (QAMS) method for the determination of seven components in Liuwei Dihuang Soft Capsule (LDSC), and to examine the feasibilities of the method for quality control of LDSC. Methods: Using LDSC as the research object, loganin was chosen as the internal reference substance by two correction methods (multipoint correction and slope correction). The relative correlation factors (f) of 5-HMF, gallic acid, morroniside, paeoniflorin, paeonol, and ursolic acid to loganin were established. The contents of seven components in 22 batches of samples were determined by the external standard method and QAMS, so as to test the accuracy. The results were compared with these two methods finally. Results: The three methods did not show significant difference in assay results according to the data. Conclusion: The QAMS method is feasible and credible, and could be used to determine and control the multiple components in LDSC.
