Application of microdialysis technique in in vivo analysis on ingredients of Chinese materia medica
10.7501/j.issn.0253-2670.2015.20.026
- Author:
Ran-Ran DONG
1
Author Information
1. Tianjin State Key Laboratory of Modern Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Chinese materia medica;
In vivo analysis;
Microdialysis technique;
Pharmacodynamic material basis;
Targeted drug delivery system
- From:
Chinese Traditional and Herbal Drugs
2015;46(20):3117-3124
- CountryChina
- Language:Chinese
-
Abstract:
Due to the complications of Chinese materia medica (CMM) and its preparations, traditional sampling methods have some limitations and affect the analysis on the ingredients of CMM. The review mainly introduced the principles, system compositions, characteristics of the microdialysis technique according to 70 literatures in the late 10 years, especially its applications on the analysis on CMM in vivo, such as in brain, skin, blood, eyes, intestinal, joint, liver, gallbladder kidney, and lung. Among these organs, brain and skin studies have more experiences. As a sampling method, microdialysis technique can not only reveal the change process of ingredients in CMM, but also can help the development of targeted drug delivery, which has the great value and good perspective in the modernization study on CMM.
