Research progress on hypolipidemic constituents in Alismatis Rhizoma and their pharmacology and clinical application
10.7501/j.issn.0253-2670.2015.22.023
- Author:
Zhi-Hong CHENG
1
Author Information
1. National Pharmaceutical Engineering Research Center, China State Institute of Pharmaceutical Industry
- Publication Type:Journal Article
- Keywords:
Alismatis Rhizoma;
Alisol A;
Alisol A 24-acetate;
Anti-atherosclerosis;
Hypolipidemia
- From:
Chinese Traditional and Herbal Drugs
2015;46(22):3420-3426
- CountryChina
- Language:Chinese
-
Abstract:
Alismatis Rhizoma, as a Chinese materia medica with multiple uses, has a long history of application in China. By retrieving the published literature of hypolipidemic effect, this review presents an overview of Alismatis Rhizoma, including chemistry, pharmacological mechanisms, clinical application, and safety evaluation. The protostane triterpenoids, as alisol A and alisol A 24-acetate, had hypolipidemic effects. Early preliminary clinical studies have shown that the Alismatis Rhizoma extraction may be a good hypolipidemic drug. Modern pharmacologic study found that it had anti-atherosclerotic effects. The reported safety evaluation results showed that the extraction was with low liver and kidney toxicity and might be suitable for long term use. We think it is worth to be developed a new drug.
