Multi-targets network construction of main effective compounds of San-ao Decoction
10.7501/j.issn.0253-2670.2015.22.014
- Author:
Hong LIU
1
Author Information
1. Basic Medical College of Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Asthma;
Ingredients;
Network pharmacology;
San-ao Decoction;
Targets
- From:
Chinese Traditional and Herbal Drugs
2015;46(22):3370-3376
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effective components and mechanism of San-ao Decoction for treating asthma by network pharmacology study, and to investigate the correlations among multi-compounds, multi-targets and multi-pathways. Methods: Effective formulaes for asthma in which effect index had been tested were searched in the past 20 years' literature. Major active compounds from the formulae consisted of Chinese medicines with representative compatibility relation were analyzed. The components-proteins networks based on PharmMappear database were built. The targets information access was used to construct and visualize components-targets-pathways network model using Boao pathway database and Cytoscape software. Results: and Conclusion: The results showed that Ephedra sinica, Armeniacae Amarum Semen, and Glycyrrhiza uralensis which consisted San-ao Decoction were the major compatibility in formulaes for asthma. The 11 active components in San-ao Decoction involved 76 targets and 46 pathways. San-ao Decoction not only had common targets and pathways, but also had their own emphasis. This reflected the formulae effect mode of multi-components, multi-targets, and multi-pathways. It may provide references to deeper study of compatibility relation and mechanism of formulaes for asthma.
