A new alkaloid isolated from leaves of Carthamus tinctorius
10.7501/j.issn.0253-2670.2019.01.005
- VernacularTitle: 红花叶中1个新的生物碱类化合物
- Author:
Dong-Bo ZHANG
1
Author Information
1. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
4-methoxy-1-ethyl-β-carboline;
Carthamus tinctorius L.;
Carthine A;
Cytotoxicity;
Β-carboline alkaloids
- From:
Chinese Traditional and Herbal Drugs
2019;50(1):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the alkaloids from leaves of Carthamus tinctorius. Methods The alkaloids were isolated and purified by silica gel, MCI, Sephadex LH-20 column chromatographies, and semi-preparative HPLC, and their structures were elucidated by physical and spectroscopic analysis. Results A new β-carboline alkaloid, 4,9-dimethoxy-1-ethyl-β-carboline (1) along with one known analogue 4-methoxy-1-ethyl-β-carboline (2), were isolated from the leaves of C. tinctorius. Compounds 1 and 2 showed the cytotoxicity against HepG2 cell lines with IC50 values of (15.2 ± 0.58) μmol/L and (17.4 ± 0.33) μmol/L, respectively. Conclusion Compounds 1 and 2 are firstly obtained from Carthamus genus, and compound 1 is a new compound named carthine A. Both compounds 1 and 2 exhibited cytotoxicity against HepG2 cell lines.
