Chemical constituents of carboxylic acid and its derivatives in Cinnamomi Ramulus
10.7501/j.issn.0253-2670.2019.01.002
- VernacularTitle: 桂枝中羧酸及其衍生物的化学成分研究
- Author:
Dan WANG
1
Author Information
1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Carboxylic acid;
Cinnamomi Ramulus;
Dihydrophaseic acid;
Hydroxyphenylpropionic acid;
Salicylic acid
- From:
Chinese Traditional and Herbal Drugs
2019;50(1):8-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the chemical constituents of Cinnamomi Ramulus. Methods Silica gel, Sephadex LH-20 column, and sp-HPLC chromatographies were applied to separate and purify the chemical constituents, followed by various spectral analyses to determine the chemical structures. Results Fifteen carboxylic acids and its derivatives were isolated, and their structures were identified as guizhi acid A (1), dihydrophaseic acid (2), rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo [3,2,1]-oct- 8-yl)-3-methyl-2Z,4E-pentadienoic acid (3), vanillic acid (4), syringic acid (5), 4-hydroxybenzoic acid (6), E-cinnamic acid (7), E-o-hydroxycinnamic acid (8), erythro-guaiacylglycerol-8’-vanillic acid ether (9), salicylic acid (10), decumbic acid (11), hydroxyphenylpropionic acid (12), protocatechuic acid (13), E-melilotoside (14), and cryptamygin-B (15), respectively. Conclusion Fifteen compounds were successfully identified from Cinnamomi ramulus, among which 1 is a new compound and compounds 2, 3, 9-12 are isolated from the plant for the first time.
