Discussion on research ideas for process in vivo of chemical compositions from Ziziphi Spinosae Semen and its quality marker
10.7501/j.issn.0253-2670.2019.02.005
- Author:
Yan YAN
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University
- Publication Type:Journal Article
- Keywords:
Effective and active compounds;
Metabolism;
Pharmacokinetics;
Quality marker (Q-marker);
Ziziphi Spinosae Semen
- From:
Chinese Traditional and Herbal Drugs
2019;50(2):299-309
- CountryChina
- Language:Chinese
-
Abstract:
Ziziphi Spinosae Semen (ZSS), one of the major traditional Chinese medicine varieties, has been used as a sedative medicine in China for thousands of years. The classical application of ZSS is nourishing heart and tranquilizing mind, tonifying the liver, arresting the sweat and promoting the production of the body fluid. Up to now, extensive chemical studies have also been conducted, suggesting the presence of alkaloids, flavonoids, saponins, and triterpene acids. Given the chemical diversity of ZSS, it is generally considered that the biological activity and pharmacological effect were accomplished by an array of phytochemicals. Due to complicated chemical composition of ZSS, compounds can be absorbed into circulation and then converted into even more metabolites. This review summarizes the recent advances in pharmacokinetics, absorption, and distribution, as well as biotransformation and/or metabolism of chemical compounds from ZSS, which might greatly contribute to supply the research target and scientific basis in clarifying the effective substance basis and the quality marker (Q-marker) of ZSS.
