Studies on alkaloids from twigs and leaves of Ervatamia officinalis
10.7501/j.issn.0253-2670.2019.04.003
- Author:
Song-Tao LI
1
Author Information
1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University
- Publication Type:Journal Article
- Keywords:
3-oxovoacangine;
Alkaloids;
Apocynaceae;
Ervatamia officinalis Tsiang;
Geissoschizol;
Voastrictine
- From:
Chinese Traditional and Herbal Drugs
2019;50(4):802-807
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents in the twigs and leaves of Ervatamia officinalis. Methods: The chemical constituents were isolated from the total alkaloids of the twigs and leaves of Ervatamia officinalis by using silica gel, ODS, Sephadex LH-20, and HPLC. The chemical structures of the compounds were identified based on their physical and chemical properties and spectroscopic methods. Results: Fourteen alkaloids were isolated and identified as 7S-coronaridine hydroxyindolenine (1), 7S-voacangine hydroxyindolenine (2), coronaridine (3), 19S-heyneanine (4), voacangine (5), tabernaemontanine (6), dregamine (7), 3-(2-oxopropyl) coronaridine (8), 3-oxovoacangine (9), voastrictine (10), 16R,19E-isositsirikine (11), 16R,19Z-isositsirikine (12), 16R,19E-isositsirikine N4-oxide (13), and geissoschizol (14). Conclusion: Compounds 8-14 are obtained from this plant for the first time.
