Research progress on Ziziphi Spinosae Semen saponins and its biological action on nervous system
10.7501/j.issn.0253-2670.2019.05.033
- Author:
Chen-Hui DU
1
Author Information
1. School of Traditional Chinese Materia Medica, Shanxi University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Chemical distribution;
Nervous system disease;
Pentacyclic triterpenoid saponins;
Tetracyclic triterpenoid saponins;
Ziziphi Spinosae Semen
- From:
Chinese Traditional and Herbal Drugs
2019;50(5):1258-1268
- CountryChina
- Language:Chinese
-
Abstract:
Ziziphi Spinosae Semen (ZSS) is the first choice for traditional Chinese medicine in the treatment of insomnia. The saponins are the main active ingredient of ZSS. At present, 51 kinds of saponin components have been obtained from ZSS, which are mainly classified into tetracyclic triterpenes and pentacyclic triterpenoid saponins according to the aglycon structure. With the deep research on the saponins from ZSS, it has been found that it has a wide range of pharmacological effects, such as calming, anti-anxiety, anti-depression, anti-tumor, and myocardial protection. In view of the increasingly serious harm to human health caused by nervous system diseases and the important role of ZSS in the prevention and treatment of nervous system diseases, this study focused on systematically summarizing the structural types of ZSS saponins and the pharmacological effects in the nervous system to provide a scientific reference for the development and utilization of ZSS saponins.
