Biopharmaceuticals classification system (BCS) of periplocin, periplocymarin and periplogenin
10.7501/j.issn.0253-2670.2019.05.009
- Author:
Xue XING
1
Author Information
1. Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Biopharmaceuticals classification system;
Periplocin;
Periplocymarin;
Periplogenin;
Permeability;
Solubility
- From:
Chinese Traditional and Herbal Drugs
2019;50(5):1082-1087
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the biopharmaceutical classification of periplocin, periplocymarin and periplogenin by biopharmaceuticals classification system (BCS). Methods The solubility and permeability of periplocin, periplocymarin and periplogenin were studied by using experimental and computer prediction software Pipeline Pilot 8.5 and ChemDraw. These three substances were sorted based on experimental and predicted values by BCS classification method. Results According to the test results, periplocin, periplocymarin and periplogenin were classified as BCS III, which are different from the classification results predicted by different software. The permeability results based on ClgP was consistent with the experimental results; The solubility based on lgCs and the permeability based on AlgP and lgD were opposite to the experimental results. Conclusion The periplocin, periplocymarin and periplogenin are BCS III drugs, the solubility is decreased in turn, but they are still highly soluble components. The permeability is the key factor affecting its absorption. The predicted value of biopharmaceutical properties of active ingredients of A-type cardiac glycosides based on the chemical structure are significant different with the test results, for the BCS study and the in vitro and in vivo correlation evaluation of oral absorption of traditional Chinese medicine preparations containing such ingredients, it is recommended to use a variety of methods to correct the data and increase the reliability of the results.
