Sesquiterpenes from aerial parts of Hyssopus cuspidatus
10.7501/j.issn.0253-2670.2019.05.004
- Author:
Dan LIU
1
Author Information
1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology
- Publication Type:Journal Article
- Keywords:
1β,11-dihydroxy-5-eudesmene;
3-eudesmene-1β-11-diol;
Hyssopus cuspidatus Boriss.;
Sesquiterpenoids;
Spathulenol
- From:
Chinese Traditional and Herbal Drugs
2019;50(5):1049-1054
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the sesquiterpenes from the aerial parts of Hyssopus cuspidatus. Methods The compounds were isolated and purified by a combination of various chromatographic techniques including D101 macroporous adsorption resin, silica gel, ODS, Toyopearl HW-40C, Sephadex LH-20, and semi-preparative HPLC. Their structures were elucidated on the basis of physicochemical properties and spectroscopic data. Results Fifteen sesquiterpenes were isolated from the 95% EtOH extracts of H. cuspidatus and their structures were elucidated as 3-eudesmene-1β-11-diol (1), 4-eudesmene-1β,11-diol (2), 1β,11-dihydroxy-5- eudesmene (3), ent-4(15)-eudesmen-1α,11-diol (4), 7α,11-dihydroxy-cadin-10(14)-ene (5), eudesmane-1β,5α,11-triol (6), 5-epi- eudesma-4(15)-ene-1β,6β-diol (7), 4(15)-eudesmene-1β,6α-diol (8), (7R*)-opposit-4(15)-ene-1β,11-diol (9), cryptomeridiol (10), octahydro-4-hydroxy-3α-methyl-7-methylene-α-(1-methylethyl)-1H-indene-1-methanol (11), caryolane-1,9β-diol (12), (3S,5R,6S,7E)- 3,5,6-trihydroxy-7-megastigmen-9-one (13), spathulenol (14), and 4β,10α-aromadendranediol (15), respectively. Conclusion Compounds 1-15 are isolated from the plants of Hyssopus genus for the first time.
