A new glycosyl ester isolated from marine-derived Penicillium sp.
10.7501/j.issn.0253-2670.2019.11.002
- Author:
Cong WANG
1
Author Information
1. Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry, School of Chemistry and Chemical Engineering，Guangxi University for Nationalities
- Publication Type:Journal Article
- Keywords:
Antimicrobial activity;
Fumitremorgin C;
Marine-derived Penicillium sp. H1;
Pyripyropene A;
Secondary metabolite;
Xylarinonericin E
- From:
Chinese Traditional and Herbal Drugs
2019;50(11):2518-2523
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To isolate and identify the active natural products of marine-derived Penicillium sp. H1. Methods: The isolations and purifications of secondary metabolites were performed by means of column chromatography over silica gel. And their structures were elucidated through the spectroscopic analysis of MS, NMR, and specific rotations. The bioactivities were assayed by paper diffusion. Results: From the fermentation broth of marine-derived Penicillium sp. H1, five compounds were isolated and identified as xylarinonericin E (1), fumitremorgin C (2), verruculogen (3), penicillide (4), and pyripyropene A (5), respectively. Compound 1 showed moderate antifungal activity against Fusarium oxysporum f. sp. Cubense with MIC value of 32.0 μmol/mL. Compound 2 displayed antibacterial activity against Staphylococcus aureus with MIC value of 64.0 μg/mL. Conclusion: Compound 1 is a new compound. Compounds 1 and 2 exhibit moderate antimicrobial activities.
