Research progress on regulation of active constituents of Chinese materia medica on G2/M phase of tumor cells
10.7501/j.issn.0253-2670.2019.15.029
- Author:
Miao YU
1
Author Information
1. Research Center of Medicine Engineering Technology, Harbin University of Commerce
- Publication Type:Journal Article
- Keywords:
Active ingredient of Chinese materia medica;
Cell cycle;
DNA damage;
G2/M phase regulation;
Mitotic defects;
Tumor cells
- From:
Chinese Traditional and Herbal Drugs
2019;50(15):3707-3713
- CountryChina
- Language:Chinese
-
Abstract:
According to the literatures at home and abroad, this paper comprehensively summarized and analyzed the research progress of regulation ways and means of various active ingredients of Chinese materia medica (CMM) on G2/M phase of tumor cells in recent years. Most of the active ingredients of CMM cause mitotic disaster of tumor cells by affecting Cyclin-CDK complex or inducing mitotic catastrophe in tumor cells, inducing DNA damage, mitotic defects and cytokinesis failure, thereby blocking tumor cells in G2/M phase, thus inhibiting tumor cell proliferation and finally inducing apoptosis. The active constituents of CMM can inhibit tumor growth and induce apoptosis by up-regulating or inhibiting key genes at the G2/M detection site, arresting tumor cells in G2/M phase, thereby exerting antitumor effects.
